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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. Administration of a marketed drug to a patient for an off-label indication without approval from a local IRB is permissible in which of the following situations?

A) The patient's physician has filed a Notice of Claimed Investigational Exemption for a New Drug with the FDA.
B) The drug is administered under a protocol sponsored by an NIH grant.
C) The drug is administered on the request of the patient or the patient's representative.
D) The patient's physician considers that the risk/benefit ratio favors the use of the drug.

2. The Randomized Aldactone Evaluation Study (RALES) yielded the following results:
* Placebo death rate: 386/841
* Spironolactone death rate: 284/822
Given these data, which of the following is the relative risk reduction for death with spironolactone, in comparison with placebo?

A) 11%
B) 45%
C) 31%
D) 24%

3. A 59-year-old man presents to the neurology clinic with recently diagnosed Parkinson's disease.
At his last visit 2 months ago, selegiline therapy was instituted, and he is tolerating it well. The patient still complains of tremor and rigidity that are interfering with both professional and leisure activities. Which option is most appropriate at this time?

A) Change to entacapone.
B) Change to ropinirole.
C) Change to amantadine.
D) Change to carbidopa/levodopa.

4. A 60-year-old man who is HIV-positive describes symptoms of erectile dysfunction and requests therapy. Current medications include tenofovir 300 mg orally daily, emtricitabine 200 mg orally daily, atazanavir 300 mg orally daily, and ritonavir 100 mg orally daily. In addition to counseling on preventing HIV transmission, which recommendation is appropriate?

A) Start sildenafil 25 mg/dose (maximum 25 mg in 48 hours) and decrease atazanavir to
150 mg orally daily.
B) Start sildenafil 50 mg/dose (maximum 200 mg in 48 hours).
C) Start sildenafil 25 mg/dose (maximum 25 mg in 48 hours).
D) Start sildenafil 50 mg/dose (maximum 200 mg in 48 hours) and decrease atazanavir to
150 mg orally daily.

5. The risk of methemoglobinemia is highest with the use of:

A) benzocaine 20% topical cream in a 42-year-old for pain associated with insect bites.
B) benzocaine 6% topical cream in a 25-year-old for pain associated with a sunburn.
C) benzocaine 10% oral gel in a 67-year-old for oral pain associated with ill-fitting dentures.
D) benzocaine 7.5% oral gel in an 18-month-old for oral pain associated with teething.

Solutions: