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American Society of Microbiology ABMM Exam Syllabus Topics:
| Section | Objectives |
|---|---|
| Infectious Disease Principles | - Pathogenesis
|
| Laboratory Management & Quality Systems | - Quality assurance and quality control
|
| Clinical Microbiology | - Mycology
|
| Laboratory Operations | - Instrumentation and methodologies
|
American Society of Microbiology ABMM Sample Questions:
A patient develops a febrile illness with jaundice and dark urine after receiving a blood transfusion.
Laboratory testing reveals an elevated level of unconjugated bilirubin and a positive direct Coombs test.
Serological testing is positive for antibodies against a protozoan parasite that infects erythrocytes. The MOST likely causative agent is:
- A. Babesia microti
- B. Plasmodium falciparum
- C. Toxoplasma gondii
- D. Trypanosoma cruzi
Correct Answer: A 🗳️
A Klebsiella pneumoniae isolate from a bloodstream infection shows the following susceptibility profile:
Meropenem (MIC = 8 µg/mL, R), Imipenem (MIC = 16 µg/mL, R), Ertapenem (MIC = 4 µg/mL, R), Ceftazidime/avibactam (MIC = 1 µg/mL, S), Aztreonam (MIC = 32 µg/mL, R). Which resistance mechanism is most strongly suggested by this pattern?
- A. Klebsiella pneumoniae Carbapenemase (KPC) production
- B. Metallo-beta-lactamase (MBL) production
- C. AmpC beta-lactamase hyperproduction coupled with porin loss
- D. Extended-Spectrum Beta-Lactamase (ESBL) production alone
Correct Answer: A 🗳️
A patient who received a solid organ transplant develops a pneumonia. Bronchoalveolar lavage fluid is positive for a single-stranded RNA virus that can cause giant cell formation with intranuclear and intracytoplasmic inclusions. The MOST likely causative agent is:
- A. Respiratory syncytial virus (RSV)
- B. Parainfluenza virus
- C. Adenovirus
- D. Human metapneumovirus
Correct Answer: B 🗳️
A clinical microbiology laboratory is using CRISPR-based technology for rapid and sensitive detection of specific bacterial DNA sequences directly from patient samples. This method relies on the ability of the Cas enzyme to:
- A. Amplify target DNA sequences using specific primers and thermal cycling.
- B. Specifically bind to and cleave target DNA sequences guided by a short RNA molecule.
- C. Reverse transcribe RNA into complementary DNA.
- D. Detect the presence of specific antibodies produced in response to bacterial infection.
Correct Answer: B 🗳️
A researcher is investigating the mechanism of action of a novel antibacterial agent that inhibits bacterial protein synthesis. The agent binds to the 50S ribosomal subunit and prevents the translocation of peptidyl- tRNA. This mechanism of action is similar to which of the following antibiotics?
- A. Ciprofloxacin
- B. Vancomycin
- C. Penicillin
- D. Azithromycin
Correct Answer: D 🗳️
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